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It is vital that all individuals with a higher risk of developing severe COVID-19, including those who are overweight or obese, are protected, as COVID-19 vaccines have demonstrated significant levels of protection against both mild and severe COVID-19 in the general population. As obesity impairs the reaction to immunizations, there is evidence that the efficiency of the seasonal influenza vaccine, among other infectious diseases, is lower in obese individuals than in individuals of a healthy weight. Therefore, it is important to research how well COVID-19 vaccinations work in obese people so that, in the event that different responses are found, alternate risk management strategies for infectious respiratory disorders might be used in this population. According to this extensive community-based cohort study, adults with overweight and obese who receive vaccinations are more protected against serious COVID-19. This extensive community-based cohort study shows that vaccination increases protection against severe COVID-19 in those with overweight and obese. Underweight individuals were shown to have reduced effectiveness, and their absorption of the vaccine was also much lower. When compared to the vaccinated population who were of a healthy weight, there were higher chances of severe COVID-19 outcomes in the vaccinated cohort for those who were obese or underweight. These findings point to the need for focused initiatives to boost uptake among those with low BMI, where it is lower and vaccine efficacy appears to be diminished. At the population level, strategies for achieving and maintaining a healthy weight should be prioritized as they may lessen the burden of COVID-19 disease.