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This is an observational study of 624 patients from two tertiary care centers in Saudi Arabia’s Eastern Province. It was aimed at assessing the impact of COVID-19 vaccination on the hospitalization rates and outcomes of hospitalized patients with COVID-19 infection.

The findings of this study are consistent with previous research which showed that unvaccinated patients have a higher risk of hospitalization. It was found that 70% of hospitalized patients in the cohort were unvaccinated. Un-vaccination was a significant predictor of critical COVID-19 disease, whereas full vaccination was associated with significantly milder disease severity. Moreover, un-vaccination status was an independent predictor of longer hospitalization, a higher requirement for ICU admission, mechanical, and death, whereas the FV group had a lower risk of ICU admission. Unvaccinated patients with comorbidities had worse severity and outcome of COVID-19 infection. Both vaccine types (Pfizer and AstraZeneca) had similar protective effects against the worst outcomes of COVID-19 disease.

To investigate the role of COVID-19 vaccination on hospitalization rate and outcomes in patients infected with COVID-19, a retrospective observational study of 1080 patients admitted with COVID-19 infection to King Fahad Hospital of the University (KFHU) and King Fahad Military Medical City (KFMMC) between April and July 2021 was conducted.

To read the full paper, please click on the linked file.