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The spread of COVID-19 among the population has posed a threat to all global healthcare institutions since March 2020. No hospital was fully prepared to manage such a rapidly spreading disease in already frail or overburdened healthcare systems. To guide further diagnosis and care, physicians needed to use deterministic thinking methods and assign pretest probabilities. This article discusses the new COVID-19 triage model, which is driven by artificial intelligence and offers an intriguing and innovative vision of what could be a future solution. COVID-19 is a threat to their organization now more than ever, as emergency department overcrowding is retaliating. In crowded departments where close proximity could promote contamination, triaging patients with potential COVID-19 infection is critical. We are confident that artificial intelligence-driven triage will meet the challenge of optimizing the early detection of patients with COVID-19 infection, reducing COVID-19 spread in emergency departments and in-hospital contamination as we face the fourth wave of COVID-19.