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This study aims to evaluate and analyze the effectiveness of the prevention and control techniques used by the United States and India during the COVID-19 outbreak in order to give empirical experience for epidemic prevention and control. To combat the two waves of the epidemic, the US implemented a number of mitigation methods, including improving virus detection, requiring individuals to wear masks, and so on. Meanwhile, India had implemented containment tactics throughout the early stages of the outbreak, resulting in a rather stable epidemic. India has shifted its focus to mitigation methods in the latter stages. Furthermore, a number of variables, including a shortage of medical resources and premature relaxation measures, contributed to the epidemic's quick progression. There are distinctions between the United States' and India's epidemic prevention efforts, particularly India's containment strategies, which helped it better, control the epidemic early on. The outbreak, however, continues to be severe in both countries. With the emergence of virus mutants and the lack of immune barriers, it is critical that the two countries continue to use non-pharmacotherapy intervention measures and accelerate vaccination, adopt containment strategies that can control the epidemic more quickly when necessary, and pay attention to the risk of epidemic rebound caused by premature relaxation of epidemic prevention policies, according to specific national circumstances.

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