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This study attempts to establish the connection of high HIV prevalence in Indian districts with socio-demographic characteristics, economic factors, awareness about HIV and Sexually Transmitted Infections (STIs), and condom use. The study uses principle component analysis on data collected from all 640 districts of India. The results from the study suggest that population size, urbanization, higher levels of literacy, better socioeconomic status, a higher proportion of the population in reproductive age groups, and late marriages are positively associated with high HIV prevalence in most regions consistently. On the other hand, knowledge about the role of condoms in HIV prevention and condom use was associated with low HIV prevalence. However, factors affecting HIV prevalence were found to be varied suggesting the need for region-specific strategies for HIV prevention. This research can help guide advocacy and assist implementers and service providers of HIV programs in program design and implementation.
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