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This cross‐sectional study conducted at an Antiretroviral Treatment (ART) center in Karnataka, examines the Quality of Life (QoL) of people living with HIV/AIDS (PLHIV) and has integrated these findings into a single regression model. This study confirms that psychological issues and level of education are the main predictors of the Quality of Life for PLHIV across the globe. Given that depression is the most significant factor, this study recommends that primary care physicians for PLHIV should also be trained to handle psychosocial management. These findings are a useful reference for primary care medical professionals, caregivers, and community health workers for improving the quality of care for PLHIV.
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