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Immunization Stress Related Responses: A Manual

09 Jan 2021
Health System Strengthening

by WHO 90 min read

The term “immunization stress-related response” (ISRR) refers to the entire spectrum of manifestations (symptoms and signs) of a stress response that may occur in the immunization process. Individual responses to stress vary from person to person or may change according to time or context. ISRR includes responses before, during and after the vaccine is administered. This Manual by the WHO contains guidance on identification and classification of ISRR, traces its epidemiology, and provides approaches for its prevention, diagnosis and management. This document can equip program managers at local, regional and national levels and healthcare professionals with technical knowledge to prevent identify, manage and respond to both individual and clusters of ISRR.  

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