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This guidance by the Global Accelerated Action for the Health of Adolescents (AA-HA!) represents a paradigm shift while approaching adolescents’ health by moving away from conventional public health lenses of risk and traditional adolescent health programing into Adolescent Health in All Policies (AHiAP) and including adolescents who face disproportionate risks due to humanitarian crises. The guidance provides 70 case studies of good practices and is useful for policymakers, donors, CSOs.