Evidence

HIV infections are associated with haematological changes, such as anemia and pancytopenia.  The haematopoietic system is the system in the body involved in the creation of the cells of blood. These changes are likely to occur due to modified hematopoietic stem/progenitor cells (HSPCs) and hematopoietic potential of the host. Therefore, a cure for HIV disease should not only consider the absence of newly HIV-infected CD4+ cells, but also the normal production rates of CD4+ T cells and other hematopoietic cells. To achieve a HIV cure, it is essential to protect bone marrow hematopoietic functions. This review of Gene Therapy approaches, shows the current evidence of modified bone marrow hematopoietic potential in HIV infection, and goes on to prove how anti-HIV gene therapy methods applied to HSPCs could support the preservation of hematopoietic potential and a functional cure. The paper also provides an overview of various gene therapy methods that could be used for this purpose. This research offers valuable information to researchers and medical professionals working in the area of HIV treatment and cure. 

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