This section hosts guidelines, manuals and toolkits to strengthen public health practice.
Studies have consistently found that undernutrition is associated with increased tuberculosis incidence, increased severity, worse treatment outcomes, and increased mortality. This report highlights nutrition-related immunocompromisation, implications of undernutrition for tuberculosis treatment and prevention, the role of nutritional supplementation, pharmacokinetics and pharmacodynamics of antimycobacterial medications in undernourished people with tuberculosis, and the role of social protection interventions in addressing undernutrition as a tuberculosis risk factor. It recommends prioritizing research to understand the immunological pathways being impaired by nutrient deficiencies, develop tools to diagnose clinical and subclinical tuberculosis in undernourished people, and understand how nutritional status affects the efficacy of tuberculosis vaccine and therapy. It also recommends accelerating policy change , particularly in countries with a high burden of tuberculosis, through primary research, modelling, and implementation research. Click here to read the report.