This section hosts guidelines, manuals and toolkits to strengthen public health practice.
Despite significant efforts, global COVID-19 vaccination coverage is lagging. Dose-reduction strategies for COVID-19 vaccines have the potential to increase vaccine availability in response to the global crisis. Several clinical trials examining dose sparing are currently being conducted. To quickly provide solid scientific justification for various dose-sparing strategies, however, joint coordinated action involving both public and private parties is required. In this article, we provide examples of vaccine dose-sparing approaches that have previously been evaluated in clinical trials to improve vaccine availability, as well as a reflection on the source of their funding. We emphasize the importance of expedited testing of vaccine dose-sparing strategies in endemic or epidemic infectious diseases, with a focus on the current COVID-19 pandemic.